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Updated: May 28, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Understanding Catalytic Enantioselective C-H Bond Oxidation at Nonactivated Methylenes Through Predictive Statistical
Arnau Call1, Andrea Palone1, Jordan P Liles2
1Institut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, Campus Montilivi, Girona E-17071, Catalonia, Spain.
None:
Enantioselective C(sp3)-H bond oxidation is a powerful strategy for installing functionality in C(sp3)-H rich molecules. Site- and enantioselective oxidation of strong C-H bonds in monosubstituted cyclohexanes with hydrogen peroxide catalyzed by aminopyridine manganese catalysts in combination with alkanoic acids has been recently described. Mechanistic uncertainties and nonobvious enantioselectivity trends challenge development of the full potential of this reaction as a powerful synthetic tool. Herein, we apply predictive statistical analysis to identify mechanistically informative correlations that provide valuable reaction understanding and will guide the future development and optimization of enantioselective C-H oxidation reactions.
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