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Hodgkin Lymphoma Treatment With Brentuximab Vedotin in a Patient With HIV, Liver Failure, and Anemia Without

Ellen Marin1, Aseala Abousaud1, Kathleen Davis1

  • 1Department of Hematology and Medical Oncology Winship Cancer Institute Emory University School of Medicine Atlanta Georgia USA.

Ejhaem
|February 13, 2025
PubMed

Brentuximab vedotin (BV) is a drug that has improved outcomes in classical Hodgkin lymphoma (cHL). However, its safety and efficacy in patients living with HIV who present with severe liver failure and life-threating cytopenias is unclear. Here, we describe the case of a woman living with HIV diagnosed with cHL and how she recovered from a hemoglobin nadir of 24 g/L despite declining transfusion support and a bilirubin peak of 417.24 µmol/L, eventually achieving a complete response with a BV-based therapy. Studies are needed to determine the safety and efficacy of BV in patients excluded from the pivotal trials. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.

Keywords:
HIVHodgkin lymphomaJehovah's Witnessanemiabrentuximab vedotincase reportliver failure

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