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Updated: May 28, 2025

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

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Carcinogenic and anticancer activities of microbiota-derived secondary bile acids

Mobina Kouhzad1, Friedrich Götz2, Tahereh Navidifar3

  • 1Department of Genetics, Faculty of Science, Islamic Azad University North Tehran Branch, Tehran, Iran.

Frontiers in Oncology
|February 13, 2025
PubMed

Insights

Secondary bile acids (SBAs) from gut microbes have a dual role in cancer, promoting it through DNA damage and oxidative stress, yet also fighting it by inducing apoptosis. Understanding this balance is key for new cancer therapies.

Area of Science:

  • Microbiology
  • Metabolomics
  • Oncology

Background:

  • Gut microbiota produce secondary bile acids (SBAs), metabolites with complex roles in health and disease.
  • SBAs have been linked to both the development and inhibition of cancer.
  • Their dualistic nature necessitates a deeper understanding of their molecular mechanisms.

Purpose of the Study:

  • To review the dual role of secondary bile acids (SBAs) in carcinogenesis and anticancer processes.
  • To explore the molecular mechanisms underlying the effects of SBAs.
  • To discuss the implications for cancer prevention and therapy.

Main Methods:

  • Literature review of studies on secondary bile acids and cancer.
  • Analysis of molecular mechanisms of SBA action.
  • Synthesis of information on host-SBA interactions.

Main Results:

  • SBAs can promote cancer via DNA damage, oxidative stress, and altered signaling pathways.
  • Certain SBAs exhibit anticancer effects by inducing apoptosis, inhibiting proliferation, and modulating immunity.
  • Host genetics and environment significantly influence SBA impact.

Conclusions:

  • SBAs possess both carcinogenic and anticancer properties, highlighting a complex biological role.
  • Targeted strategies are needed to mitigate risks and leverage beneficial SBA effects.
  • Understanding the SBA equilibrium is crucial for developing novel cancer therapeutics.
Keywords:
anticancerbile acidscarcinogenicmicrobiotasecondary bile acids

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