Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.0K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bacillus sp. S361 isolated from bioaerosols in pharmaceutical wastewater treatment plants aggravates Klebsiella pneumoniae-induced lung injury in rats by modulating the gut microbiota.

Journal of hazardous materials·2025
Same author

An innovative hippocampal-sparing whole-brain radiotherapy planning approach via the Halcyon system: achieving lower hippocampal doses.

Frontiers in oncology·2025
Same author

Integrated bulk and single-cell RNA sequencing identifies oxidative stress signatures of radiation-induced lung injury in mice through machine learning.

The international journal of biochemistry & cell biology·2025
Same author

Accelerating multi-directional diffusion MRI through patch-based joint reconstruction.

NeuroImage·2025
Same author

Dosimetric impacts on height development after radiotherapy for intracranial non-germinomatous germ cell tumors.

International journal of radiation biology·2025
Same author

Dosimetric comparison and evaluation of different convergence modes in nasopharyngeal carcinoma using VMAT treatment deliveries.

PeerJ·2024

Related Experiment Video

Updated: May 28, 2025

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations
04:46

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations

Published on: February 24, 2023

1.4K

Risk factors and risk prediction model for recurrence in medulloblastoma.

Ruyu Ai1, Qiandong Liang2, Guanhua Deng1

  • 1Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou, China.

Translational Pediatrics
|February 13, 2025
PubMed
Summary

Neutrophil-to-lymphocyte ratio (NLR) and molecular subtypes improve medulloblastoma recurrence prediction. A new nomogram integrating these factors aids in personalized treatment strategies for better patient outcomes.

Keywords:
Medulloblastomamodelpredictionrecurrencerisk factors

More Related Videos

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
05:10

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

12.1K
Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
06:32

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

16.2K

Related Experiment Videos

Last Updated: May 28, 2025

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations
04:46

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations

Published on: February 24, 2023

1.4K
Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
05:10

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

12.1K
Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
06:32

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

16.2K

Area of Science:

  • Pediatric Oncology
  • Cancer Genomics
  • Immunology

Background:

  • Established treatment protocols for recurrent medulloblastoma are lacking.
  • Accurate pre-treatment risk assessment is crucial for tailoring medulloblastoma treatment intensity.
  • A predictive model for medulloblastoma recurrence is needed for clinical decision-making.

Purpose of the Study:

  • To develop an enhanced risk prediction model for medulloblastoma relapse.
  • To integrate molecular subtyping and neutrophil-to-lymphocyte ratio (NLR) into a nomogram for improved prediction.
  • To aid clinical decision-making in medulloblastoma management.

Main Methods:

  • Retrospective analysis of 273 medulloblastoma patient records.
  • Calculation of pre-radiotherapy neutrophil-to-lymphocyte ratio (NLR).
  • Utilized Kaplan-Meier, Cox regression, and nomogram construction for prognostic factor identification and validation.

Main Results:

  • Independent prognostic factors for progression-free survival (PFS) included age, residual tumor volume, NLR > 4.5, dissemination, and Group 3 molecular subtype.
  • The nomogram achieved a C-index of 0.749 (training) and 0.736 (validation).
  • The nomogram demonstrated significant stratification of low-risk versus high-risk groups (P<0.001).

Conclusions:

  • Pre-treatment NLR is an independent prognostic marker for medulloblastoma recurrence and metastasis.
  • The developed nomogram integrating NLR and clinical variables can predict PFS post-radiotherapy.
  • This nomogram facilitates accurate risk stratification and personalized treatment for medulloblastoma patients.