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Association between parental high-sensitive C-reactive protein and hypertension in offspring: an intergenerational

Xuemei Yang1,2, Feipeng Cui3, Shuohua Chen4

  • 1Department of Rheumatic Disease, Kailuan General Hospital, Tangshan, China.

Clinical Hypertension
|February 13, 2025
PubMed

Insights

Parental high-sensitive C-reactive protein (hs-CRP) levels are linked to an increased risk of hypertension in offspring. This study explored the association between parental hs-CRP and offspring hypertension, finding a significant correlation.

Area of Science:

  • Cardiovascular Health
  • Inflammation Biomarkers
  • Genetics and Heredity

Background:

  • The link between C-reactive protein (CRP) and hypertension is established.
  • The association between parental high-sensitive CRP (hs-CRP) and offspring hypertension is not well understood.
  • Investigating intergenerational links in cardiovascular risk factors is crucial.

Purpose of the Study:

  • To examine the relationship between parental and offspring hs-CRP levels.
  • To determine if parental hs-CRP levels are associated with offspring hypertension.
  • To assess the combined effect of parental and offspring hs-CRP on hypertension risk.

Main Methods:

  • Utilized data from 6,848 father-offspring and 1,588 mother-offspring pairs from the Kailuan study.
  • Calculated time-weighted average hs-CRP (TWA-CRP) for parental and offspring cohorts.
  • Employed generalized estimating equation and Cox proportional hazard models to analyze associations.

Main Results:

  • High parental TWA-CRP was associated with increased offspring TWA-CRP (regression coefficient 0.50-0.53).
  • High parental TWA-CRP correlated with higher odds of offspring hypertension (OR 1.30-1.32).
  • Concurrence of high parental and offspring TWA-CRP significantly elevated offspring hypertension risk (OR 1.92-2.44).

Conclusions:

  • Parental hs-CRP levels may serve as a predictive marker for offspring hypertension.
  • Elevated hs-CRP in parents warrants attention for potential cardiovascular risks in their children.
  • Further research into the mechanisms linking parental inflammation and offspring hypertension is recommended.
Abstract

Keywords:
CRPEpidemiologyHypertensionIntergenerational relations

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