Metal catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides: structural diversity at the dipole partner
Juan Carlos Carretero1,2, Nuria Rodríguez1,2, Javier Adrio1,2
1Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049, Madrid, Spain. n.rodriguez@uam.es.
Abstract:
The 1,3-dipolar cycloaddition of azomethine ylides represents a versatile approach for synthesizing pyrrolidines, valuable structural motifs in synthetic and medicinal chemistry. However, most studies to date have relied predominantly on α-iminoesters as ylide precursors, thereby limiting the broader synthetic applications of this strategy. This feature article highlights alternative azomethine ylide precursors, beyond conventional α-iminoesters, which have facilitated the preparation of pyrrolidines with new subtitution patterns.
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