Time in Target Range, All-Cause Mortality, and Cardiovascular Diseases

Area of Science:

• Cardiology
• Public Health
• Hypertension Research

Background:

• Systolic blood pressure (SBP) time in target range (TTR) assesses blood pressure (BP) control.
• Understanding the impact of different SBP TTRs on mortality and cardiovascular disease (CVD) risk is crucial for patient outcomes.

Purpose of the Study:

• To compare the risk of all-cause mortality and cardiovascular diseases (CVDs) in individuals with over 50% of their SBP within various target ranges.
• To investigate the association between high SBP TTR and adverse health events.

Main Methods:

• Analysis of 40,914 participants with complete BP data, free of CVDs and cancer.
• Calculation of SBP TTR using four SBP records over six years.
• Follow-up for mortality and CVD events through medical records and death certificates.

Main Results:

• During follow-up (median 8.78 years), 2,398 deaths and 1,995 CVD events occurred.
• Participants with >50% TTR >150mmHg showed a 1.67-fold higher risk of all-cause mortality and a 2.06-fold higher risk of CVDs compared to those with >50% TTR <120mmHg.
• These increased risks remained significant after adjusting for covariates and excluding specific subgroups.

Conclusions:

• Achieving over 50% time in a high SBP target range (>150mmHg) is a significant predictor of all-cause mortality and cardiovascular diseases.
• Maintaining blood pressure within optimal, lower target ranges is critical for reducing long-term health risks.