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Pathogenetic observations on pleural effusion disease in rabbits
Archives of Virology
|January 1, 1985
Summary
A study on rabbit pleural effusion disease (PED) found that virulent PED virus (PEDV) caused fatal illness, while avirulent strains caused mild infections. Virulent virus became less potent over time, and immunity developed gradually.
Area of Science:
- Veterinary Virology
- Pathogenesis Research
- Rabbit Disease Models
Background:
- Pleural effusion disease (PED) is a significant concern in rabbit populations.
- The etiological agent, PED virus (PEDV), has both virulent and avirulent forms.
- Understanding PEDV pathogenesis is crucial for disease management.
Purpose of the Study:
- To investigate the pathogenetic differences between virulent and avirulent PEDV isolates in rabbits.
- To elucidate the mechanisms of virulence and immune response to PEDV infection.
- To explore the potential role of selective pressure in PEDV virulence.
Main Methods:
- Infection of rabbits with virulent and avirulent PEDV isolates.
- Monitoring of clinical signs, virus titration in serum, and viraemia levels.
- Assessment of immune protection following virulent challenge.
Main Results:
- Virulent PEDV caused fatal disease, while avirulent PEDV resulted in subclinical infection, irrespective of dose.
- Virulent virus gradually lost virulence during viraemia.
- Protective immunity developed progressively, with full protection achieved by week four.
Conclusions:
- PEDV virulence is influenced by factors such as the interval between rabbit passages.
- Benign passenger viruses can emerge as significant pathogens under specific selective pressures.
- PEDV pathogenesis involves a dynamic interplay between viral virulence and host immunity.
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01:25Pleural Effusion I: Introduction
Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
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01:28Pleural Effusion II: Symptoms and Management
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations: