Related Experiment Video

Updated: May 28, 2025

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma
10:02

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

1.8K

Challenges and Emerging Strategies of Immunotherapy for Glioblastoma

Mingchuan Mao1, Yao Lei2, Xianbin Ma1

  • 1School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China.

Chembiochem : a European Journal of Chemical Biology
|February 13, 2025
PubMed

Insights

Glioblastoma (GBM) remains a deadly brain cancer. Immunotherapy, including oncolytic viruses and CAR T cells, shows promise for GBM treatment, especially when combined with traditional therapies.

Area of Science:

  • Neuro-oncology
  • Cancer Immunology
  • Translational Medicine

Background:

  • Glioblastoma (GBM) is the most lethal primary malignant brain tumor.
  • Current treatments offer limited survival benefits, necessitating novel therapeutic strategies.
  • Immunotherapy has emerged as a promising avenue for GBM treatment.

Purpose of the Study:

  • To systematically review the characteristics of Glioblastoma.
  • To summarize recent advancements in immunotherapy for GBM treatment.
  • To explore combination strategies involving immunotherapy and conventional therapies.

Main Methods:

  • Literature review of Glioblastoma features and immunotherapy approaches.
  • Analysis of current research on oncolytic viruses, checkpoint inhibitors, CAR T cells, and tumor vaccines.
  • Evaluation of studies combining immunotherapy with radiotherapy, chemotherapy, and gene therapy.

Main Results:

  • Immunotherapy offers a new effective modality for GBM treatment.
  • Various immunotherapy types, including oncolytic viruses and CAR T cells, are being investigated.
  • Combination therapies show potential for improved treatment outcomes.

Conclusions:

  • Immunotherapy represents a significant advancement in the fight against Glioblastoma.
  • Combining immunotherapy with traditional treatments may enhance efficacy.
  • Further research into novel immunotherapy strategies is crucial for improving GBM patient prognosis.
Keywords:
Keywords: Glioblastoma; Immunotherapy; Treatment Dilemma; Immunotherapy Strategy

More Related Videos

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

21.3K
Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations04:46

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations

Published on: February 24, 2023

1.4K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
464
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
329