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Updated: May 5, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Molecular Circuit-Controlled Nanoparticle Folders for Programmable DNA Information Access.

Ranfeng Wu¹, Yongpeng Zhang², Jiongjiong Teng²

¹School of Computer Science and Technology, Dalian University of Technology, Dalian 116024, China.

|February 13, 2025

Summary

This study introduces a programmable DNA data access strategy using DNAzyme circuits and nanoparticle folders for efficient information retrieval. This innovation enhances DNA data storage and computing systems.

Keywords:

DNA circuit DNA storage DNAzyme regulation data access molecular programming nanoparticle folder

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Last Updated: May 5, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami

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Published on: December 3, 2015

Design and Synthesis of a Reconfigurable DNA Accordion Rack

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Published on: August 15, 2018

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Area of Science:

Biotechnology
Molecular Engineering
Data Science

Background:

DNA offers high-density, stable digital data storage.
Current DNA data access methods rely on PCR and hybridization, lacking dynamic programmability.
Need for advanced methods for efficient and accurate molecular data reading.

Purpose of the Study:

To propose a programmable DNA data access strategy using DNAzyme circuits and nanoparticle folders.
To demonstrate dynamic and programmable information manipulation for DNA data access.
To enable selective information retrieval from DNA data pools.

Main Methods:

Utilized DNAzyme circuits to control nanoparticle folders for information manipulation.
Experimentally demonstrated YES, AND, and OR logic circuit programs for data access.
Extended the framework for multiple manipulation modes on gold nanoparticle (AuNP) folders.

Main Results:

Successfully accessed specific information using programmable DNAzyme circuits.
Achieved selective information retrieval from a DNA data pool.
Demonstrated on-demand access to different information via multiple manipulation modes.

Conclusions:

The proposed programmable access strategy offers a new paradigm for integrated DNA computing and storage.
This approach enhances the efficiency and programmability of molecular data access.
Potential applications in molecular computation, DNA data storage, and beyond.