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Isolation and Chemical Characterization of Lipid A from Gram-negative Bacteria
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Silyl-Lipid Functionalized N-Acyl Homoserine Lactones as Modulators of Bacterial Cell-Cell Communication

Linnea S Dolph1, Emma E Santa2, Irene M Stoutland2

  • 1Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.

ACS Chemical Biology
|February 13, 2025
PubMed
Summary

Researchers developed novel silyl-lipid derivatives of N-acyl homoserine lactones (AHLs) with potent nanomolar activity against bacterial quorum sensing receptors. These compounds offer new tools for studying bacterial communication and developing antimicrobials.

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