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Bioinformatic analysis and experimental validation implicate STAT2-mediated angiogenic responses in rosacea

Bancheng Chen1, Chenchen Wu1, Yan Liao1

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This study identifies distinct molecular patterns in rosacea based on angiogenesis genes. STAT2 protein is elevated in a specific rosacea subtype and promotes blood vessel formation, suggesting it as a potential therapeutic target.

Keywords:
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Area of Science:

  • Dermatology
  • Molecular Biology
  • Immunology

Background:

  • Rosacea is a chronic inflammatory skin condition.
  • Vascular abnormalities are implicated in rosacea pathogenesis.
  • Distinct angiogenic molecular patterns exist in rosacea lesions.

Purpose of the Study:

  • To characterize rosacea subtypes based on angiogenic gene expression.
  • To investigate immune cell infiltration in relation to angiogenic patterns.
  • To explore the role of STAT2 in rosacea angiogenesis.

Main Methods:

  • Analysis of the GSE65914 dataset for gene expression.
  • Identification of immune signatures in rosacea subtypes.
  • Validation of STAT2 expression in rosacea patients and a mouse model.
  • In vitro experiments on human umbilical vein endothelial cells (HUVECs).

Main Results:

  • Rosacea samples were classified into distinct angiogenic molecular patterns.
  • Unique immune signatures were associated with VEGFAhigh MMP9low and VEGFAlow MMP9high subtypes.
  • STAT2 protein levels were higher in the VEGFAhigh MMP9low group and confirmed in rosacea patients and a mouse model.
  • STAT2 knockdown inhibited HUVEC tube formation, indicating its role in angiogenesis.

Conclusions:

  • Rosacea can be subtyped by distinct angiogenic molecular profiles.
  • STAT2 plays a critical role in regulating angiogenic responses in rosacea.
  • STAT2 represents a potential therapeutic target for rosacea treatment.