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Impacts of Excessive Iron Intake on Infant Growth and Fluorimetric and Colorimetric Detection Methods: A
Alaa Shafie1, Amal Adnan Ashour2, Faris J Tayeb3
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O.Box 11099, Taif, 21944, Saudi Arabia. A.shafie@tu.edu.sa.
Insights
Excess iron negatively impacts children's growth. Advanced sensing techniques help detect iron levels, aiding early diagnosis and intervention for pediatric iron overload.
Area of Science:
- Biochemistry
- Pediatric Health
- Analytical Chemistry
Background:
- Iron is vital for physiological processes but excess iron accumulation causes adverse effects on growth and development.
- Maintaining optimal iron levels is critical in pediatric health, as both deficiency and overload present significant risks.
- Accurate detection of iron (Fe2+/Fe3+) levels in biological samples is essential for early diagnosis and intervention of iron overload.
Purpose of the Study:
- To investigate the impact of excess iron on children's growth parameters.
- To review recent advancements in organic colorimetric and fluorometric probes for sensitive iron detection.
- To provide insights for public health policies and clinical strategies for healthy pediatric development.
Main Methods:
- Exploration of the impact of excess iron on pediatric growth parameters.
- Review of recent (2022-2024) advancements in organic colorimetric and fluorometric probes.
- Analysis of sensing techniques for Fe2+/Fe3+ detection in biological matrices.
Main Results:
- Excess iron accumulation adversely affects children's growth and development.
- Fluorometric and colorimetric sensing techniques enable accurate Fe2+/Fe3+ detection.
- Recent probes show high sensitivity and selectivity for trace-level iron detection.
Conclusions:
- Optimal iron levels are crucial for pediatric health.
- Advanced sensing technologies facilitate early diagnosis and management of iron overload.
- Findings can inform public health policies and clinical strategies for healthy child development.
Abstract:
Iron is an essential nutrient involved in various physiological processes, including oxygen transport, enzyme activity, and cellular metabolism. However, excessive iron accumulation in the body can disrupt this delicate balance, leading to adverse effects on growth and development. Maintaining optimal iron levels is crucial for pediatric health, as both deficiency and overload pose significant risks. Fluorometric and colorimetric sensing techniques play a vital role in accurately detecting Fe2+/Fe3+ levels in biological matrices, facilitating early diagnosis and intervention in cases of iron overload. This study explores the impact of excess iron on children growth parameters, offering insights that can inform public health policies and clinical strategies for promoting healthy development. Additionally, this review highlights recent advancements (2022-2024) in organic colorimetric and fluorometric probes, which exhibit high sensitivity and selectivity for Fe2+/Fe3+ detection at trace levels.
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