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Related Experiment Video

Updated: May 28, 2025

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

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Published on: April 14, 2014

OCT-Based Retina Assessment Reflects Visual Impairment in Multiple Sclerosis.

Natacha Stolowy^1,2, Lilija Gutmann³, Margareta Lüpke³

¹APHM, Hopital de la Conception, Department of Ophthalmology, Marseille, France.

Investigative Ophthalmology & Visual Science

|February 13, 2025

Summary

This summary is machine-generated.

Optical coherence tomography (OCT) reveals retinal thinning in multiple sclerosis (MS) patients. Macular ganglion cell layer (mGCIPL) volume is the best indicator of vision loss and neurodegeneration in MS.

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Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

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Published on: January 12, 2022

Area of Science:

Ophthalmology
Neuroscience
Medical Imaging

Background:

Multiple Sclerosis (MS) is a demyelinating disease affecting the central nervous system.
Visual impairment is common in MS, impacting quality of life.
Optical Coherence Tomography (OCT) is a non-invasive imaging technique to assess retinal structure.

Purpose of the Study:

To investigate the correlation between visual function and retinal layer thickness in people with MS (PwMS) compared to healthy controls (HC).
To evaluate the efficacy of OCT in detecting visual impairment in PwMS.
To compare different visual acuity tests and their association with retinal morphology.

Main Methods:

Data collected from 137 PwMS and 118 HC at two neurology centers.
Neurological, ophthalmological assessments, including OCT, high-contrast visual acuity (HCVA), low-contrast visual acuity (LCVA), and area under the log contrast sensitivity function (AULCSF).
Follow-up assessments conducted after one year.

Main Results:

PwMS showed reduced peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGCIPL) volume compared to HC.
Specific cutoffs for pRNFL thickness were associated with visual impairment (HCVA, LCVA, AULCSF).
mGCIPL volume was most strongly associated with AULCSF, and AULCSF correlated best with both pRNFL and mGCIPL.

Conclusions:

AULCSF is a sensitive measure of visual function, closely mirroring retinal atrophy.
mGCIPL loss is a stronger indicator of neurodegeneration and visual impairment than pRNFL, without a cutoff effect.
OCT, particularly mGCIPL measurement, is a valuable tool for assessing neuronal atrophy in MS.