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Clinical Features, Complications, and Treatment Outcomes of Pediatric Pars Planitis Cases in a Tertiary Referral

Duygu Gülmez Sevim1, Hidayet Sener1, Furkan Ozer2

  • 1Department of Ophthalmology, Erciyes University Medical Faculty, Kayseri, Turkey.

Ocular Immunology and Inflammation
|February 13, 2025
PubMed

Insights

Pediatric pars planitis (PPP) treatment with immunosuppressants effectively reduces inflammation and improves vision. Early intervention is key for optimal visual outcomes in children with PPP.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Uveitis Management

Background:

  • Pediatric pars planitis (PPP) is a form of intermediate uveitis affecting children.
  • Understanding its clinical course and treatment outcomes is crucial for effective management.

Purpose of the Study:

  • To detail the clinical manifestations, ocular complications, and treatment results of pediatric pars planitis (PPP).

Main Methods:

  • Retrospective study of 28 children (51 eyes) aged 16 or younger.
  • Data collected included visual acuity, inflammation grades, macular thickness, and treatment approaches.
  • Analysis of outcomes at 3, 6, 9, and 12 months post-treatment.

Main Results:

  • Significant visual acuity improvement within the first 3 months (p=0.025).
  • Marked reduction in anterior chamber cells and vitritis grade after treatment.
  • Initial macular edema present in 27% of eyes, with 57% showing reduced central macular thickness post-treatment.

Conclusions:

  • Immunosuppressive therapy effectively controls intraocular inflammation in pediatric pars planitis.
  • Treatment should focus on inflammation, macular edema, and papillitis.
  • Early diagnosis and aggressive treatment are vital for preserving visual prognosis.
Abstract

Keywords:
Adalimumabmacular edemamethotrexatepediatric intermediate uveitisvitritis

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