Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

633
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
633
T Cell Types and Functions01:24

T Cell Types and Functions

938
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
938

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expansion and safety profile of CD28-costimulated anti-CD19 CAR T cells in B-cell lymphoma versus autoimmune disease.

HemaSphere·2026
Same author

Evidence for early, clinically silent medial temporal lobe inflammation after CAR-T cell therapy.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Rescue of mitochondrial and neurite pathology in <i>SPG7</i> hereditary spastic paraplegia patient-derived cortical neurons.

Brain communications·2026
Same author

Corrigendum to "Metabolic plasticity and optimal redox homeostasis are essential for efficient metastatic colonization" [Mol Metab 109 (2026) 102382/42155637].

Molecular metabolism·2026
Same author

Organelle proteomics reveals novel metabolic vulnerabilities in FLT3-ITD cells.

Leukemia·2026
Same author

Epcoritamab in Richter Transformation: Insights from a Real-World Case Series.

Blood advances·2026

Related Experiment Video

Updated: May 28, 2025

Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

187

Metabolic T-cell phenotypes: from bioenergetics to function.

Nouria Jantz-Naeem1, Nese Guvencli2, Romy Böttcher-Loschinski2

  • 1Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

American Journal of Physiology. Cell Physiology
|February 13, 2025
PubMed
Summary

T-cell metabolism reprogramming is crucial for immune response. Understanding altered metabolic profiles in T cells is key for developing personalized immunotherapies for various diseases.

Keywords:
T cellsautoimmunitycancerimmunometabolismviral infection

More Related Videos

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
06:55

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

3.8K
Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
06:22

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

12.9K

Related Experiment Videos

Last Updated: May 28, 2025

Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

187
Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
06:55

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

3.8K
Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
06:22

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

12.9K

Area of Science:

  • Immunology
  • Cellular Metabolism
  • Systems Biology

Background:

  • T-cell function is intrinsically tied to their metabolic state.
  • Metabolic reprogramming supports T-cell energy demands and biosynthesis.
  • Dysfunctional T-cell metabolism can drive disease pathology.

Purpose of the Study:

  • To review metabolic alterations in T-cell subsets across different diseases.
  • To highlight the role of immunometabolism in T-cell bioenergetics.
  • To identify therapeutic targets within T-cell metabolism.

Main Methods:

  • Literature review of immunometabolism studies.
  • Analysis of metabolic changes in T-cell subsets.
  • Integration of data from autoimmune, viral, and malignant conditions.

Main Results:

  • Specific T-cell subsets exhibit distinct metabolic profiles.
  • Metabolic reprogramming is altered in autoimmune diseases, viral infections, and cancers.
  • Aberrant T-cell metabolism impacts disease progression and immune response.

Conclusions:

  • Understanding T-cell metabolic endotypes is vital for personalized medicine.
  • Targeting immunometabolism offers potential therapeutic strategies.
  • Further research into T-cell bioenergetics can advance immunotherapy.