Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sensory Functions of the Skin01:16

Sensory Functions of the Skin

4.4K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
4.4K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

832
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
832
What is the Immune System?01:38

What is the Immune System?

110.1K
Overview
110.1K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

66.7K
Overview
66.7K
Cell-surface Signaling01:21

Cell-surface Signaling

51.4K
Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
51.4K
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

1.3K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunonutrition in Early Life: The Role of Complementary Feeding, Dietary Patterns, and Nutritional Exposures on the Health of Young Children-An EAACI Scoping Review.

Allergy·2026
Same author

Diet-Microbiome-Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications.

Allergy·2026
Same author

Bridging Rare to Common Diseases: Precision Medicine and the Transforming Landscape of Pediatric Allergy and Immunology.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Nutritional, growth, and microbiome implications of oral immunotherapy: Unintended consequences and clinical considerations.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report.

Allergy·2026
Same author

ZENIA: Development of an AI-driven nutrition app to support immune health: An EAACI task force report.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026

Related Experiment Video

Updated: May 28, 2025

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

18.2K

Skin-deep immune sensing.

Nonhlanhla Lunjani1, Liam O'Mahony2

  • 1APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Dermatology, University Hospital Limerick, Limerick, Ireland.

Cell Host & Microbe
|February 13, 2025
PubMed
Summary
This summary is machine-generated.

Recent studies reveal how skin B cells create antibody responses to microbes. They identified a key target in Staphylococcus epidermidis for developing new topical vaccines.

More Related Videos

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

10.6K
Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
10:45

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

10.7K

Related Experiment Videos

Last Updated: May 28, 2025

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

18.2K
Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

10.6K
Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
10:45

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

10.7K

Area of Science:

  • Immunology
  • Microbiology
  • Dermatology

Background:

  • The skin hosts a diverse microbiome, including Staphylococcus epidermidis.
  • B cells play a crucial role in adaptive immunity, including antibody production.
  • Understanding skin-resident immune responses is vital for developing effective therapies.

Purpose of the Study:

  • To elucidate the mechanisms of autonomous B cell antibody responses in the skin.
  • To identify specific microbial targets for enhancing skin immunity.
  • To explore the potential for engineering topical vaccination strategies.

Main Methods:

  • Analysis of B cell populations and antibody production in skin models.
  • Identification of immunodominant antigens from Staphylococcus epidermidis.
  • In silico and in vitro validation of vaccine strategies.

Main Results:

  • Detailed characterization of skin-autonomous B cell activation pathways.
  • Discovery of a specific Staphylococcus epidermidis antigen as a key target for antibody responses.
  • Demonstration of the feasibility of using this target for topical vaccine development.

Conclusions:

  • Skin B cells mount robust antibody responses to resident microbes.
  • Targeting specific microbial antigens, like those from Staphylococcus epidermidis, can inform novel vaccine design.
  • These findings pave the way for innovative topical vaccination approaches to enhance skin immunity.