Related Experiment Video
Updated: May 11, 2026
10:34
Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
Published on: August 30, 2020
10.3K
Atraumatic Subdural Hematoma in a Patient on Adalimumab
Anthony V Nguyen1, Bronson M Ciavarra1, Muralidhar Jatla2,3
1Department of Neurosurgery, Baylor Scott and White Health, Temple, Texas.
Pediatrics
|February 13, 2025
Summary
A rare case of atraumatic subdural hematoma (SDH) occurred in a pediatric patient treated with adalimumab. The patient recovered after surgery and switching to ustekinumab, suggesting a potential link between adalimumab and SDH.
Area of Science:
- Pediatric Neurology
- Gastroenterology
- Rheumatology
Background:
- Atraumatic subdural hematoma (SDH) is uncommon in pediatric patients.
- Adalimumab, a biologic therapy, is FDA-listed as a potential cause of SDH, but clinical reports are scarce.
Purpose of the Study:
- To report a case of pediatric atraumatic subdural hematoma in a patient receiving adalimumab therapy.
- To discuss the potential association between adalimumab and SDH in this patient population.
Main Methods:
- A 16-year-old male with ulcerative colitis on adalimumab presented with neurological symptoms.
- Cranial imaging revealed a significant left-sided subdural hematoma with midline shift.
- Surgical evacuation of the hematoma was performed, and alternative etiologies were excluded.
Main Results:
- The patient was diagnosed with a chronic subdural hematoma.
- Post-operative recovery was successful, and the patient was transitioned to ustekinumab.
- No recurrence of SDH was observed after adalimumab discontinuation.
Conclusions:
- This case highlights a rare instance of atraumatic subdural hematoma in a pediatric patient on adalimumab.
- Discontinuation of adalimumab and initiation of ustekinumab led to a favorable outcome.
- Further investigation into the potential link between adalimumab and SDH is warranted.
More Related Videos
Related Concept Videos
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
01:26Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...