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Related Concept Videos

Fatigue01:21

Fatigue

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
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The pathophysiology of pneumonia involves the following steps:
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Long-term Depression01:05

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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COPD: Pathogenesis and Clinical Features01:20

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Related Experiment Video

Updated: May 28, 2025

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Focusing on post-COVID syndrome fatigue.

M Gómez-Eguílaz1, S López-Alava1, J L Ramón-Trapero2

  • 1Servicio de Neurología, Hospital Universitario San Pedro, Logroño, Spain.

Neurologia
|February 13, 2025
PubMed
Summary

Post-COVID fatigue, a common symptom of post-COVID syndrome, showed moderate intensity and affected quality of life. While physical fatigue improved, psychological fatigue persisted, suggesting a potentially self-limiting condition requiring further study.

Keywords:
COVID prologadoCOVID-19FatigaFatiguePost-COVID syndromeProlonged COVIDSARS-CoV-2Sleep disorderSíndrome post-COVIDTrastorno del sueño

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Over 100 million globally infected with SARS-CoV-2, leading to COVID-19.
  • Post-COVID syndrome involves persistent symptoms, with fatigue being the most common neurological manifestation.
  • Understanding post-COVID fatigue is crucial for managing long-term health consequences.

Purpose of the Study:

  • To investigate the characteristics and impact of post-COVID fatigue.
  • To compare fatigue in post-COVID syndrome patients with COVID-19 survivors without fatigue.
  • To analyze associated factors including sleep, mood, cognition, and quality of life.

Main Methods:

  • Prospective, single-center, case-control study.
  • Inclusion of patients with and without post-COVID fatigue, assessed at baseline and 6 months.
  • Data collection included clinical variables, fatigue scales, sleep, depression, anxiety, cognitive function, quality of life, and cytokine analysis (IL-6, IL-1β, TNF-α, IL-10).

Main Results:

  • Post-COVID fatigue was mixed (physical/psychological) and moderate.
  • Physical fatigue improved at 6 months, but psychological fatigue did not.
  • Significant differences noted in sleepiness, cognitive impairment, anxiety, quality of life, and TNF-α levels.

Conclusions:

  • Patients with post-COVID fatigue experienced poorer quality of life.
  • A 6-month improvement suggests a potentially self-limiting course for post-COVID fatigue.
  • Longer-term studies are needed to confirm the self-limiting nature of this condition.