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Updated: May 28, 2025
Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
Published on: April 13, 2022
Current applications, future Perspectives and challenges of Organoid technology in oral cancer research
Yunyi Wang1, Xiang Sun1, Bingxu Lu1
1Department of Oral and Maxillofacial Surgery, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Abstract:
Oral cancer poses significant health risks with an increasing incidence annually. Despite advancements in treatment methods, their efficacy is frequently constrained by cancer heterogeneity and drug resistance, leading to minimal improvement in the 5-year survival rate. Therefore, there is a critical need for new treatment methods leaded by representative preclinical research models. Compared to other models, organoids can more precisely simulate the tissue structure, genetic characteristics, and tumor microenvironment (TME) of in vivo tumors, exhibiting high tumor specificity. This makes organoid technology a valuable tool in investigating tumor development, mechanisms of metastasis, drug screening, prediction of clinical responses, and personalized patient treatment. Moreover, integrating organoid technology with other biotechnologies could expand its applications in tissue regeneration. Although organoid technology is increasingly utilized in oral cancer research, a systematic review in this field is absent. This paper is to bridge the gap by reviewing the development and current status of organoid research, highlighting its applications, future prospects, and challenges in oral cancer. It aims to provide novel insights into the role of organoids in precision treatment and regenerative medicine for oral cancer.
Insights
Organoid technology offers a promising preclinical model for oral cancer research, accurately mimicking tumors to improve drug screening and personalized treatments. This review highlights organoids
Area of Science:
- Biomedical Engineering
- Oncology
- Regenerative Medicine
Background:
- Oral cancer presents a significant global health challenge with limited survival rate improvements due to tumor heterogeneity and drug resistance.
- Current preclinical models often fail to fully recapitulate the complexity of oral tumors, necessitating advanced research tools.
- There is a critical need for innovative treatment strategies driven by representative and accurate preclinical models.
Purpose of the Study:
- To systematically review the development and current applications of organoid technology in oral cancer research.
- To highlight the potential of organoids in understanding oral cancer progression, metastasis, and drug response.
- To explore the future prospects and challenges of integrating organoids into precision medicine and regenerative strategies for oral cancer.
Main Methods:
- Comprehensive literature search on organoid technology and oral cancer research.
- Systematic review and synthesis of existing studies.
- Analysis of organoid applications in drug screening, clinical response prediction, and personalized treatment.
Main Results:
- Organoids closely mimic in vivo tumor structure, genetic profiles, and the tumor microenvironment (TME), demonstrating high tumor specificity.
- Organoid technology is valuable for investigating oral cancer development, metastasis, drug screening, and predicting patient treatment responses.
- Integration with other biotechnologies expands organoid applications into tissue regeneration.
Conclusions:
- Organoid technology represents a significant advancement in oral cancer preclinical research, offering high fidelity to patient tumors.
- Organoids are crucial for advancing precision treatment strategies and hold potential in regenerative medicine for oral cancer.
- This review addresses the absence of systematic analysis in this field, providing insights for future research and clinical translation.
