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Updated: Jul 21, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
New steroid and meroterpenoids from a sewage fungus Eurotium sp
Xueqiong Liu1, Zediao Huang1, Junguo Huang1
1School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
Abstract:
A new steroid, eurotether (1), and three new meroterpenoids, tricycloalternarene I (2), tricycloalternarene J (3) and (2R,3S,4aR)-altenuene-2-acetoxy ester B (4), along with six known compounds (5-10) were isolated from a sewage fungus Eurotium sp. XL-0006. Their structures were elucidated based on NMR analysis, electronic circular dichroism (ECD) calculations and single crystal X-ray diffraction experiments. Compound 1 was the first example of steroid combined with a dibenzo-α-pyrone through double oxygen bridges, and compounds 1-10 were first discovered from Eurotium genus. Compounds 1-6 were evaluated for antibacterial activities against eight clinical drug-resistant bacteria using the microbroth dilution method.
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