Related Experiment Video
Updated: Jun 13, 2025
Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
Published on: August 24, 2019
Modulating respiratory mechanics and inflammation in hepatopulmonary syndrome: Aerobic exercise as a therapeutic
César Augusto Melo-Silva1, Walter Moreno Campos Nunes2, Eloisa Sanches Pereira Nascimento2
1Laboratory of Respiratory Physiology, University of Brasilia, Brasília, DF, Brazil; Division of Physical Therapy, Brasilia University Hospital, Brasília, DF, Brazil; Graduate Program in Medical Sciences, School of Medicine, University of Brasilia, Brasília, DF, Brazil.
Introduction:
Aerobic exercise training positively modulates the immune system and improves lung function; however, its effects on respiratory system's elastic, resistive properties and interleukin-10 (IL-10) concentration in hepatopulmonary syndrome (HPS) remains unexplored. This study aimed to assess whether moderate-intensity aerobic (AE) training altered exercise capacity, respiratory mechanics and lung inflammation.
Material And Methods:
Wistar rats were randomly assigned to SHAM, HPS, HPS + AE4, and HPS + EA8 groups. The EA4 group represents AE training for 4 weeks starting 7 days after HPS induction, whereas EA8 accounts for AE training for 4 weeks before and after HPS induction, both protocols practiced 3 times weekly. Exercise capacity, respiratory mechanics, lung and systemic inflammation, and lung morphology were assessed.
Results:
Moderate aerobic exercise significantly increased the maximal running capacity of the HPS animals. The training decreased tissue elastance by 19 % (p = 0.01 compared to SHAM) and reduced frequency-dependent respiratory reactance at 0.5 Hz, 0.75 Hz, and 1.25 Hz frequencies compared to HPS animals (p < 0.05 for all). For the HPS + EA4 and HPS + EA8 groups IL-10 plasma concentration increased by 23 % and 31 % compared to SHAM (p < 0.001 both) and by 38 % and 47 % compared to HPS (p < 0.01 both). Nonetheless, AE did not alleviate lung tissue remodeling induced by HPS.
Conclusions:
Moderate-intensity aerobic training improved maximum running capacity, reduced HPS-induced respiratory mechanics derangements at the lung regional level, and increased systemic IL-10 concentration, although it did not ameliorate lung tissue remodeling.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:23Physiological Control of Respiration
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
01:26COPD: Management Using Bronchodilators and Corticosteroids
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
01:16Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...