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Published on: February 17, 2023
Recent advancements in colchicine derivatives: Exploring synthesis, activities, and nanoformulations for enhanced
Marialucia Rubicondo1, Gianluca Ciardelli1, Clara Mattu1
1Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy; Polito BIOMed Lab, Politecnico di Torino, Turin, Italy.
Abstract:
The multifaceted anti-cancer properties of colchicine make it a promising candidate for tumor treatment. However, its application has been limited by poor solubility, low bioavailability, and systemic toxicity. Considerable efforts have been directed toward the development of colchicine derivatives and nanoformulations to overcome these challenges. In this review, we provide a comprehensive overview of recent advances in colchicine derivatives and nanoformulations for cancer treatment. Synthesis methods and in vitro antiproliferative assays for the reviewed derivatives and formulations are explored. Challenges, such as drug resistance and formulation optimization, are also addressed, along with future perspectives for leveraging the full potential of colchicine derivatives and their nanoformulations as innovative anti-cancer strategies, toward successful clinical applications.
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