Difficult management of abnormal uterine bleeding in Glanzmann thrombasthenia

Glanzmann thrombasthenia (GT) is a rare haematological disorder with abnormal platelet surface receptor glycoprotein IIb/IIIa, resulting in faulty platelet aggregation. Patients with GT may present with spontaneous bleeding after trauma or surgery. As the disease is rare, controlling and preventing bleeding in such patients is challenging. We report two cases of previously diagnosed GT presented with abnormal uterine bleeding. The first case was managed medically with tranexamic acid and hormonal therapy to control menstrual bleeding. In contrast, the second case involved a tubo-ovarian endometrioma presenting with heavy menstrual bleeding (HMB) and dysmenorrhoea, which was treated with laparoscopic adhesiolysis and cyst aspiration. Management of HMB and endometriosis is challenging, especially when using invasive procedures such as laparoscopy. Physicians should be familiar with the characteristics of the disease and all possible treatment options to halt the bleeding to avoid morbidity in patients.