Determination of the residual efficacy of broflanilide (VECTRON™ T500) insecticide for indoor residual spraying in a semi-field setting in Ethiopia

Eba Alemayehu Simma ¹, Habtamu Zegeye ², Geremew Muleta Akessa ^3,4

⁰Department of Biology, Jimma University, Jimma, Ethiopia. ebasimma@gmail.com.

Malaria Journal +

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February 13, 2025

View abstract on PubMed

Summary

VECTRON™ T500 demonstrated over 80% mosquito mortality for nine months on various surfaces, outperforming Actellic 300CS in Ethiopia. This insecticide shows promise for malaria vector control and addressing insecticide resistance.

Area Of Science

Entomology
Medical Entomology
Public Health

Background

Indoor residual spraying (IRS) relies on insecticide rotation for malaria vector control and managing insecticide resistance.
Insecticide decay rates are critical for national malaria control programs.
VECTRON™ T500, containing broflanilide, is a new insecticide formulation with potential for IRS.

Purpose Of The Study

To evaluate the residual efficacy of VECTRON™ T500 against malaria vectors.
To assess VECTRON™ T500's performance on diverse wall surfaces (mud, dung, paint, cement).
To determine the decay rate of VECTRON™ T500 over time in Ethiopia.

Main Methods

Bioassays were conducted using laboratory-reared Anopheles arabiensis mosquitoes.
Seven test huts with different wall types were used: mud, dung, painted, and cemented.
Huts were treated with VECTRON™ T500, Actellic 300CS, or water (control).

Main Results

VECTRON™ T500 achieved over 80% mosquito mortality across all wall types for nine months.
Actellic 300CS maintained over 80% mortality for six months, with a sharp decline on dung surfaces thereafter.
VECTRON™ T500 exhibited superior residual efficacy compared to Actellic 300CS.

Conclusions

VECTRON™ T500 provides effective mosquito mortality for up to nine months on various surfaces.
The formulation's extended efficacy suggests it is a strong candidate for IRS programs in malaria-endemic regions.
VECTRON™ T500 could be a valuable tool in Ethiopia's malaria vector control efforts.

Keywords:

Broflanilide Ethiopia Indoor residual spraying Residual efficacy VECTRON™ T500