Relationship between serum carotenoids and osteoarthritis or degenerative arthritis: A cross-sectional study using the National Health and Nutrition Examination Survey
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View abstract on PubMed
Summary
This summary is machine-generated.Higher serum trans-lycopene concentrations may reduce osteoarthritis (OA) risk, particularly in older adults. This antioxidant effect shows a nonlinear pattern, with benefits observed above a specific threshold.
Area Of Science
- Nutritional Science
- Biochemistry
- Epidemiology
Background
- Carotenoids, known for antioxidant and anti-inflammatory effects, have an unclear link to osteoarthritis (OA).
- Understanding the relationship between carotenoid levels and OA is crucial for potential preventative strategies.
Purpose Of The Study
- To investigate the association between serum carotenoid concentrations and OA in a large American population.
- To explore how factors like age influence the carotenoid-OA relationship.
Main Methods
- Utilized data from the National Health and Nutrition Examination Surveys (2001-2006, 2017-2018).
- Employed weighted generalized linear models and restricted cubic spline models to analyze associations.
- Conducted threshold effect, subgroup, interaction, and sensitivity analyses to identify nonlinear relationships and modifiers.
Main Results
- Overall, serum carotenoid levels did not show a significant linear correlation with OA probability.
- A significant nonlinear relationship was found between trans-lycopene and OA, with a threshold effect at 19.49 µg/dl.
- Serum trans-lycopene concentrations above 19.49 µg/dl were associated with a lower OA probability, especially in older individuals.
Conclusions
- Trans-lycopene, unlike other carotenoids, demonstrates a significant, age-dependent negative correlation with OA in the American population.
- A serum trans-lycopene level above approximately 19.49 µg/dl may be protective against OA, with the effect intensifying with age.
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