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Updated: May 28, 2025
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
[Prognostic Factors in Repeat Resection for Recurrence after Liver Metastases of Colorectal Cancer]
Yuya Funatsu1, Nozomu Sakai, Tsukasa Takayashiki
1Dept. of General Surgery, Graduate School of Medicine, Chiba University.
Background:
Hepatectomy is recommended for colorectal liver metastases and repeat resection of recurrent lesions is an effective treatment for patients with recurrence. However, treatment outcomes are unclear in patients with aggressive tumor behavior.
Subjects:
Initial hepatectomy for colorectal liver metastases was performed on 180 patients between 2010 and 2021, and recurrence, treatment outcomes, and prognostic factors were analyzed.
Results:
Of the 180 patients, 124 developed recurrences, and repeat resection was performed in 58. Of these, 34 patients had liver metastasis alone, 12 had lung metastasis alone, and 2 had simultaneous liver and lung recurrence. The median overall survival(OS)and 5-year survival were significantly longer in the resectable group(70 months and 64.4%, respectively)than in the unresectable group (54 months and 35.3%, respectively). The presence of 3 or more recurrent lesions was an independent risk factor for unresectability. The time to surgical failure(TSF)was significantly shorter in patients with 3 or more recurrent lesions, suggesting that an increased number of recurrent lesions is an indicator of poor prognosis.
Conclusion:
The number of recurrent lesions post-initial hepatectomy is a risk factor for poor OS and TSF. Patients with 3 or more recurrent lesions have a higher risk of becoming unresectable early, necessitating combined resection and chemotherapy.
