[A Case of Bladder Preservation by Neoadjuvant Chemotherapy for Sigmoid Colon Cancer with Bladder Invasion]

The patient was a 76-year-old female who presented with pain during urination and turbid urine(containing fecal matter). She was referred to our urology department from a local clinic. Imaging findings indicated sigmoid colon cancer with bladder invasion. Total colonoscopy revealed a circumferential advanced sigmoid colon cancer. Abdominal contrast-enhanced computed tomography(CT)showed wail thickening of the sigmoid colon wall, with unclear demarcation from the bladder. The preoperative diagnosis was cT4b(bladder), N1b, M0, cStage Ⅲc. After construction of a colostomy, 4 course of capecitabine plus oxaliplatin with bevacizumab therapy were performed as neoadjuvant chemotherapy. Since response evaluation was partial response(PR), the pathological diagnosis was ypT4b(small intestine), N1a, M0, ypStage Ⅲc, with histological effect classificatory was 2. Postoperatively, 2 course of capecitabine plus oxaliplatin therapy and 1 course of capecitabine therapy were performed for adjuvant chemotherapy, has no relapsed for 14 months.