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Updated: May 28, 2025
Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
Published on: August 12, 2015
[Breast Cancer Therapy Strategies Based on the BRCA Pathogenic Variants]
Kana Ogisawa1, Hikari Nitahara, Saeko Henmi
1Dept. of Breast Surgical Oncology, Osaka Metropolitan University Graduate School of Medicine.
Background:
Breast cancer therapy based on the pathogenic variants of BRCA is entering a new era with the expanded use of olaparib in adjuvant chemotherapy. This study examined the timing of olaparib administration in patients with BRCA pathogenic sequence variant (PSV).
Subject And Methods:
BRCA genetic testing was performed in 281 patients at our facility between April 2019 and October 2023. These patients were retrospectively reviewed.
Result:
Seventeen(6.0%)of 281 patients were diagnosed with BRCA-PSV(+). Six patients had Stage Ⅰ disease, 5 had Stage Ⅱ disease, 2 had Stage Ⅲ disease, and 4 had Stage Ⅳ disease. One patient had a high risk of recurrence and the remaining 7 patients had experienced recurrence prior to olaparib administration.
Conclusion:
As the indications expand, the number of patients who are administered olaparib is expected to increase. Therefore, the appropriate protocols for the detection of BRCA-PSVs must be followed.
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