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Updated: May 28, 2025

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
Published on: April 17, 2020
[irAE-Related Postoperative Anastomotic Stenosis Following Gastrectomy for Gastric Cancer]
Ibuki Shibata1, Shuhei Komatsu, Tomoki Konishi
1Dept. of Digestive Surgery, Japanese Red Cross Kyoto Daiichi Hospital.
Abstract:
Despite recent advances in chemotherapy with immune-checkpoint inhibitor(ICI), some patients may have to undergo surgery after the immune-related adverse events(irAE). We report here a case of a 61-year-old man who developed the irAE-related anastomotic stenosis after robotic gastrectomy for gastric cancer. Previously, he was diagnosed as double cancers of far-advanced hung cancer and gastric cancer. He was treated with ICI-based chemotherapy comprising CBDCA, PEM and pembrolizumab for lung cancer, and developed drug-induced pneumonia and dermatomyositis due to severe irAE. Stenosis was improved with steroid therapy. Until now, there has been no recurrence without symptoms in these 2 years.
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