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Slowing Thoracic Aortic Aneurysm Growth with Statins: A Meta-Analysis
Amie Marie Kolimas1, Gargya Malla1, Abhimanyu Chadha1
1Department of Medicine, University of Arizona, Tucson, AZ 85721, United States.
Current Cardiology Reviews
|February 14, 2025
Summary
Statins may slow the growth of thoracic aortic aneurysms (TAAs), reducing dissection risk. This meta-analysis indicates a potential benefit, but further research is needed due to study heterogeneity.
Area of Science:
- Cardiovascular Medicine
- Medical Research
- Pharmacology
Background:
- Thoracic aortic aneurysms (TAAs) pose a significant dissection risk.
- Previous research suggests statins may impede TAA expansion.
- This meta-analysis investigates statin efficacy in slowing TAA growth.
Purpose of the Study:
- To consolidate evidence on statin use for slowing thoracic aortic aneurysm growth.
- To determine if statins are associated with reduced TAA expansion rates.
Main Methods:
- A systematic search identified four studies comparing TAA growth in statin users versus non-users.
- The primary outcome was the annual TAA growth rate, analyzed using a random-effects model.
- Statistical heterogeneity was assessed using I2 statistics, with p<0.05 considered significant.
Main Results:
- Four studies included 757 statin users and 1,696 controls.
- Pooled analysis revealed statins were associated with slower TAA growth (SMD -0.70 mm/year; p=0.01).
- High heterogeneity (I2=95%) was observed among the included studies.
Conclusions:
- This meta-analysis suggests statins are linked to slower thoracic aortic aneurysm growth.
- Results indicate a potential therapeutic benefit of statins in managing TAAs.
- Caution is advised when interpreting findings due to significant heterogeneity in the source studies.
Keywords:
Thoracic aortaaneurysmdata analysis.heterogeneitymetalloproteasesstatinsthoracic aortic aneurysmsMore Related Videos
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