Related Experiment Video
Updated: May 28, 2025
Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
Published on: March 1, 2011
Interleukin-38 as a potential diagnostic biomarker for heart failure
Hongman Liu1, Mingliang Zhang1, Wen Gong1
1Department of Cardiology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China.
Objective:
Interleukin-38 (IL-38) attenuates inflammation, myocardial injury, and ventricular remodeling after myocardial infarction, which potentially reduces the incidence of heart failure (HF). This study aimed to evaluate the diagnostic value of IL-38 for HF.
Methods:
IL-38 was detected via enzyme-linked immunosorbent assay in the serum samples of 238 hF patients and 30 healthy controls when enrollment.
Results:
IL-38 was elevated in HF patients compared with controls (p = 0.002). Receiver operating characteristic (ROC) analysis showed that the area under the curve (AUC) of IL-38 for predicting HF risk was 0.676 (95% confidence interval = 0.594-0.758). The Youden index of IL-38 for diagnosing HF peaked at 0.329 when the cutoff value of IL-38 was set as 6 ng/mL, with sensitivity and specificity of 0.833 and 0.496, respectively. Before (odds ratio = 1.493, p = 0.002) and after (odds ratio = 1.500, p = 0.007) adjustment of age and gender by multivariable regression analysis, IL-38 was associated with a higher HF risk. Moreover, the combination of IL-38 with age and gender possessed a good value for predicting HF risk (AUC = 0.796, 95% confidence interval = 0.706-0.885).
Conclusion:
IL-38 is increased in HF patients compared with controls, and its combination with age and gender shows a good value for the diagnosis of HF.
More Related Videos
08:16An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses
Published on: July 7, 2017
10:12A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
Published on: August 8, 2013
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:17Pathophysiology of Heart Failure