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Updated: May 28, 2025

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Published on: December 16, 2021
B-cell Acute Lymphoblastic Leukemia in a Patient With Crohn's Disease After Anti-TNF-Alpha Treatment
Abded Alraouf Kawtharani1, Laura Akiki1, Abbas Rachid2
1Gastroenterology and Hepatology, Faculty of Medicine, Lebanese University, Beirut, LBN.
Abstract:
This case report details a patient with Crohn's disease (CD) who developed acute lymphoblastic leukemia (ALL) 16 years after their initial diagnosis. Various immunosuppressive therapies used in the treatment included azathioprine, infliximab and, for a short period, vedolizumab and steroids for CD and hyper-CVAD chemotherapy for leukemia. The association between CD and increased cancer risk, particularly hematological malignancies, emphasizes the importance of regular cancer surveillance, including hematological assessments, for patients on immunosuppressive therapy.
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