Risk factors for malignancy in pediatric subacute/chronic focal craniocervical lymphadenopathy
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.In children with persistent neck lymphadenopathy, older age and larger lymph nodes are key indicators of potential malignancy. These factors help guide decisions for surgical intervention in pediatric cases.
Area Of Science
- Pediatric Oncology
- Head and Neck Surgery
- Diagnostic Imaging
Background
- Focal persistent isolated craniocervical lymphadenopathy is common in children.
- Malignancy risk is generally low, but identifying high-risk cases is crucial for timely intervention.
- Decisions regarding surgical excision require accurate risk stratification.
Purpose Of The Study
- To identify factors associated with malignancy in children with focal persistent isolated craniocervical lymphadenopathy.
- To assist in clinical decision-making regarding nodal surgical excision in pediatric patients.
- To improve the diagnostic accuracy for malignancy in pediatric neck masses.
Main Methods
- Retrospective analysis of demographic and clinical data from children treated between January 2008 and December 2020.
- Inclusion of children with subacute and chronic craniocervical lymphadenopathy from a tertiary pediatric ambulatory clinic.
- Univariate and multivariate analyses were performed to assess risk factors for malignancy.
Main Results
- Of 450 children, 5.6% were diagnosed with malignancy.
- Factors associated with malignancy included older age, larger nodal size, specific lymph node locations (supraclavicular, lateral cervical), and systemic symptoms.
- Multivariate analysis confirmed older age (OR 1.649 per 3 years) and larger lymph nodes (OR 2.080 per cm) as significant predictors of malignancy.
Conclusions
- Older age and increased lymph node size are significant indicators of malignancy risk in children with craniocervical lymphadenopathy.
- These findings support considering surgical intervention for children presenting with these risk factors.
- Improved identification of high-risk pediatric patients can lead to earlier diagnosis and treatment.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...