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Immune checkpoint inhibitors: Utilizing patient's own immunity to treat oral cancer

Rashmi Gs Phulari1, Bharvi Solanki1

  • 1Department of Oral and Maxillofacial Pathology and Microbiology, Manubhai Patel Dental College and Hospital and Oral Research Institute, Vishwajyoti Ashram, Near Vidyakunj School, Maunjmauda, Vadodara, Gujarat, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|February 14, 2025
PubMed

Insights

Head and Neck squamous cell carcinoma (HNSCC) is immunosuppressive. Immunotherapy, particularly targeting programmed cell death 1 (PD-1), shows promise for recurrent and metastatic HNSCC, improving patient prognosis.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Head and Neck squamous cell carcinoma (HNSCC) creates an immunosuppressive tumor microenvironment.
  • HNSCC employs various mechanisms to evade immune surveillance and response.

Purpose of the Study:

  • To review the role of immune checkpoint molecules in HNSCC.
  • To discuss the efficacy of immunotherapy, including checkpoint inhibitors like PD-1, as monotherapy and combination therapy for HNSCC.

Main Methods:

  • Literature review of clinical trials and research on HNSCC immunotherapy.
  • Analysis of immune checkpoint molecule function and their impact on HNSCC.

Main Results:

  • Immune checkpoint inhibitors, especially targeting programmed cell death 1 (PD-1), demonstrate significant promise in treating recurrent and metastatic HNSCC.
  • Combination immunotherapies are being explored for enhanced treatment efficacy.

Conclusions:

  • Understanding the tumor microenvironment and immune regulators is crucial for advancing HNSCC treatment.
  • Immunotherapy represents a vital therapeutic strategy for improving outcomes in HNSCC patients.
Keywords:
Head and neck squamous cell carcinomaimmune checkpoint inhibitorsimmunotherapyoral cancer

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