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Updated: May 5, 2026
Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
Histomorphometric analysis of lichen planus and lichenoid lesions - Retrospective study
Manti Vijayalakshmi1, Bandela Rajasekhar1, Vishwaprakash Shetty1
1Department of Oral and Maxillofacial Pathology, Lenora Institute of Dental Sciences, Rajanagaram, Rajahmundry, Andhra Pradesh, India.
Introduction:
Though it has a different aetiology, lichenoid lesions and lichen planus are both chronic inflammatory mucocutaneous conditions with similar clinical and histological characteristics. Uncertainty persists despite the development of recommendations for distinguishing oral lichen planus from lichenoid diseases.
Materials And Methodology:
A retrospective analysis was conducted on 25 cases of oral lichen planus (OLP), oral lichenoid lesions (OLL), and normal oral mucosa (NOM) that had been histologically diagnosed. Using imagej analysis software, morphometric assessments of the cellular area, nuclear area, nucleus cytoplasmic ratio, nuclear diameter, and cellular diameter of suprabasal cells were performed on sections stained with haematoxylin and eosin. The data were then analysed using ANOVA.
Results:
Our study's findings demonstrated that, in comparison to the normal oral mucosa, the mean values of the nuclear area, cellular area, nuclear diameter, and cellular diameter in oral lichen planus and oral lichenoid lesions were higher.
Conclusion:
In the current investigation, we also found that, in comparison to normal mucosa, the nuclear-cytoplasmic ratio was lower in oral lichen planus and oral lichenoid lesions.
