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Updated: May 28, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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cGAS/STING signaling pathway in gynecological malignancies: From molecular mechanisms to therapeutic values

Danyang Zhang1, Bingxue Zhang1

  • 1Department of Obstetrics, The First Hospital of China Medical University, Shenyang, Liaoning, China.

Frontiers in Immunology
|February 14, 2025
PubMed

Insights

The cGAS/STING pathway plays a dual role in gynecological cancers, impacting tumor immunity and evasion. Targeting this pathway offers potential for novel cancer therapies and improved patient outcomes.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Gynecological cancers (cervical, ovarian, endometrial) pose a significant global health challenge.
  • Disparities in prevention (HPV vaccination, screening) worsen disease burden.
  • The cGAS/STING pathway is crucial for innate immunity, detecting cytosolic DNA and initiating immune responses.

Purpose of the Study:

  • To explore the dual role of the cGAS/STING pathway in gynecological cancers.
  • To investigate its influence on tumor microenvironments, immune surveillance, and inflammation.
  • To review therapeutic strategies targeting the cGAS/STING pathway for improved cancer treatment.

Main Methods:

  • Review of literature on cGAS/STING signaling in gynecological cancers.
  • Analysis of molecular mechanisms linking DNA damage response and immune modulation.
  • Examination of therapeutic potential of STING agonists, PARP inhibitors, and immunotherapies.

Main Results:

  • The cGAS/STING pathway can either promote antitumor immunity or facilitate tumor immune evasion.
  • Its activation or suppression significantly impacts ovarian, cervical, and endometrial cancers.
  • Therapeutic strategies show promise in enhancing immune responses and overcoming resistance.

Conclusions:

  • The cGAS/STING pathway is a critical regulator in gynecological cancer progression and immune response.
  • Targeting cGAS/STING signaling holds potential for novel therapeutic interventions.
  • Future research directions include personalized treatments leveraging this pathway for enhanced immunotherapy efficacy.
Keywords:
DNA damage responsePARPiSTINGcGAScervical cancerendometrial cancerimmunotherapyovarian cancer

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