Related Experiment Video
Updated: May 28, 2025
Reducing State Anxiety Using Working Memory Maintenance
Published on: July 19, 2017
Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major
Fanxi Ding1, Yiyang Ying2, Yuqing Jin3
1Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, School of Brain Science and Brain Medicine, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Background:
It has been well established that psychiatric disorders are often accompanied by cognitive dysfunction. Previous studies have investigated the verbal fluency task (VFT) for detecting executive function impairment in different psychiatric disorders, but the sensitivity and specificity of this task in different psychiatric disorders have not been explored. Furthermore, clarifying the mechanisms underlying variations in executive function impairments across multiple psychiatric disorders will enhance our comprehension of brain activity alternations among these disorders. Therefore, this study combined the VFT and the functional near-infrared spectroscopy (fNIRS) to investigate the neural mechanisms underlying the impairment of executive function across psychiatric disorders including anxiety disorder (AD), sleep disorder (SD) and major depressive disorder (MDD).
Methods:
Two hundred and eight participants were enrolled including 52 AD, 52 SD, 52 MDD and 52 healthy controls (HCs). All participants completed the VFT while being monitored using fNIRS to measure changes in brain oxygenated hemoglobin (Oxy-Hb).
Results:
Our results demonstrated that MDD, AD and SD exhibited decreased overall connectivity strength, as well as reduced connected networks involving the frontal and temporal regions during the VFT comparing to HC. Furthermore, the MDD group showed a reduction in connected networks, specifically in the left superior temporal gyrus and precentral gyrus, compared to the AD group.
Conclusion:
Our study offers neural evidence that the VFT combined with fNIRS could effectively detect executive function impairment in different psychiatric disorders.
More Related Videos
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
04:33Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Related Concept Videos
01:18Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
01:30Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...