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Severe hypocalcemia and hypophosphatemia following Denosumab administration in a multi-comorbidity patient

Anuja Sagdeo1, Mahmoud Elshehawy2, Chadi Rakieh3

  • 1Diabetes and Endocrinology, The Shrewsbury and Telford Hospitals NHS Trust, UK.

Medicine and Pharmacy Reports
|February 14, 2025
PubMed

Insights

This case study highlights denosumab-induced hypocalcemia and hypophosphatemia in an elderly patient with osteoporosis. Management involved mineral supplementation and drug discontinuation, emphasizing vigilant monitoring for complex patients.

Area of Science:

  • Endocrinology
  • Geriatric Medicine
  • Pharmacology

Background:

  • Osteoporosis management in elderly patients often involves complex medical histories.
  • Denosumab is a common treatment for osteoporosis, but potential side effects require careful consideration.

Observation:

  • An elderly patient with osteoporosis and comorbidities developed severe hypocalcemia and hypophosphatemia during denosumab treatment, despite calcium and vitamin D supplementation.
  • The patient's condition necessitated a multidisciplinary team (MDT) approach for management.

Findings:

  • Discontinuation of denosumab was crucial for recovery.
  • Intravenous and oral mineral supplementation led to gradual normalization of calcium and phosphate levels.

Implications:

  • Vigilant monitoring for electrolyte disturbances is essential in patients receiving denosumab, especially those with multiple comorbidities.
  • This case underscores the importance of individualized treatment plans and careful risk-benefit assessment when prescribing denosumab for osteoporosis in complex patients.

Keywords:
Denosumabhypocalcaemiahypophosphatemiaosteoporosis

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