Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the

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Shiming Tan1, Shizhen Li1, Longzheng Xia1

  • 1The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer Metabolism, Changsha, Hunan 410013, P.R. China.

International Journal of Oncology
|February 14, 2025
PubMed

Insights

Long non-coding RNA ABHD11-AS1 acts as a tumor suppressor in colorectal cancer (CRC). Its reduced expression promotes CRC progression by activating the EGFR/ERK pathway, suggesting a new therapeutic target for CRC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) play a role in colorectal cancer (CRC) development.
  • The specific function of lncRNA ABHD11-AS1 in CRC remains largely unexplored.

Purpose of the Study:

  • To investigate the role of lncRNA ABHD11-AS1 in regulating the biological behavior of CRC cells.
  • To elucidate the underlying molecular mechanisms of ABHD11-AS1 in CRC progression.

Main Methods:

  • Bioinformatic analysis, reverse transcription-quantitative PCR, and in situ hybridization were used to assess ABHD11-AS1 expression.
  • Functional assays (proliferation, migration, invasion) were performed to evaluate the impact of ABHD11-AS1.
  • Interaction studies with EGFR and analysis of the EGFR/ERK signaling pathway were conducted.

Main Results:

  • ABHD11-AS1 expression was decreased in CRC tissues and correlated with poor prognosis.
  • Overexpression of ABHD11-AS1 suppressed CRC cell proliferation, migration, and invasion.
  • ABHD11-AS1 interacted with EGFR, inhibiting its phosphorylation and attenuating the EGFR/ERK signaling pathway.

Conclusions:

  • lncRNA ABHD11-AS1 functions as a tumor suppressor in colorectal cancer.
  • The ABHD11-AS1/EGFR/ERK signaling axis represents a potential therapeutic target for CRC intervention.
Keywords:
ABHD11‑AS1EGFRSPT6colorectal cancerresveratrol

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