Growth and Growth-Promoting Treatments in Turner Syndrome
Roopa Kanakatti Shankar1,2, Charmian A Quigley3, Tsuyoshi Isojima4
1Division of Endocrinology, Children's National Hospital, Washington, District of Columbia, USA.
Summary
Short stature in Turner syndrome can be addressed with timely growth hormone therapy, promoting catch-up growth. Individualized treatment and shared decision-making are key for realistic expectations and near-normal adult height.
Area of Science:
- Pediatrics
- Endocrinology
- Genetics
Background:
- Short stature is a primary concern for children with Turner syndrome.
- Turner syndrome affects growth and development, necessitating effective management strategies.
Purpose of the Study:
- To review data informing the 2024 international consensus guidelines for Turner syndrome.
- To discuss growth hormone therapy and alternative agents for Turner syndrome.
Main Methods:
- Review of natural history of growth in Turner syndrome.
- Analysis of safety and efficacy data for recombinant human growth hormone (rhGH) therapy.
- Consideration of emerging growth-promoting agents.
Main Results:
- Timely rhGH therapy can mitigate growth failure and promote catch-up growth.
- Individual responses to rhGH vary based on factors like age, baseline height, and estrogen initiation.
- Near-normal adult height is achievable for many individuals with appropriate treatment.
Conclusions:
- Growth hormone therapy is effective but requires individualized treatment plans.
- Shared decision-making and realistic goal-setting are crucial for managing expectations.
- Updated guidelines emphasize personalized approaches to growth promotion in Turner syndrome.
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