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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Epigenetics Modulators as Therapeutics for Neurological Disorders.

Mansi Gaba1, Ashwani Sharma2, Nitin Chitranshi3

  • 1School of Pharmaceutical Sciences, MVN University, Palwal, Haryana, India.

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|February 14, 2025
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Summary

Epigenetic mechanisms influence neurological disorders. Epigenetic therapies show promise for treating conditions like Alzheimer's and Parkinson's by targeting gene expression, but challenges remain.

Keywords:
DNA methylationEpigeneticsepigenetic modulatorshistone modificationneurological disorderstherapeutic interventions.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Epigenetic mechanisms (DNA methylation, histone modification, non-coding RNAs) are vital for gene expression and neural plasticity.
  • Dysregulation of these epigenetic processes is implicated in the pathogenesis of neurological disorders such as Alzheimer's disease, Parkinson's disease, and epilepsy.

Purpose of the Study:

  • To review recent findings on epigenetic therapies for neurological disorders.
  • To discuss the potential benefits and challenges of using epigenetic modulators in clinical settings.

Main Methods:

  • Review of current clinical trials and research on epigenetic modulators.
  • Analysis of epigenetic mechanisms including DNA methyltransferase and histone deacetylase inhibitors.

Main Results:

  • Epigenetic modulators offer a promising strategy to correct aberrant epigenetic marks and restore neurological homeostasis.
  • These interventions have the potential to halt or reverse disease progression, offering targeted and neuroprotective effects.

Conclusions:

  • Epigenetic therapies present a novel approach for treating neurological disorders.
  • Key challenges include ensuring specificity, effective delivery, and long-term efficacy of these treatments.