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Published on: June 7, 2015
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Catheter Injectable Multifunctional Biomaterial for the Treatment of Infected Enterocutaneous Fistulas
Jinjoo Kim1, Zefu Zhang1, Hassan Albadawi1
1The Laboratory for Patient-Inspired Engineering, Mayo Clinic, 13400 East Shea Blvd., Scottsdale, AZ, 85259, USA.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|February 14, 2025
Summary
A novel hydrogel, 18NC75-10P-1IL, effectively treats enterocutaneous fistulas (ECF) by promoting healing and fighting resistant infections. This biomaterial shows promise for clinical application in ECF management.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Infectious Diseases
Background:
- Enterocutaneous fistulas (ECF) present significant treatment challenges, leading to high morbidity and mortality.
- Antibiotic-resistant infections and chronic inflammation complicate conventional ECF treatment.
- There is a critical need for innovative biomaterials to manage ECF effectively.
Purpose of the Study:
- To develop and evaluate a multi-functional hydrogel, 18NC75-10P-1IL, for the treatment of enterocutaneous fistulas.
- To assess the injectability, mechanical properties, pro-healing, and antimicrobial efficacy of the engineered hydrogel.
- To determine the biocompatibility and therapeutic potential of 18NC75-10P-1IL in preclinical models.
Main Methods:
- Fabrication of a shear-thinning hydrogel (18NC75-10P-1IL) using gelatin, nanosilicates, an ionic liquid, and platelet-rich fibrin fraction.
- Characterization of mechanical properties for catheter injectability and durable occlusion.
- In vitro antimicrobial testing against patient-derived, antibiotic-resistant bacteria.
- In vivo evaluation in subcutaneous implantation and anorectal fistula models.
Main Results:
- The hydrogel 18NC75-10P-1IL exhibited tailored mechanical properties for effective catheter injection and fistula occlusion.
- Demonstrated significant pro-healing effects and potent antimicrobial activity against resistant ECF-associated bacteria.
- Preclinical models confirmed biocompatibility, pro-healing, anti-inflammatory, and antimicrobial properties.
Conclusions:
- The multi-functional hydrogel 18NC75-10P-1IL is a promising candidate for the clinical treatment of enterocutaneous fistulas.
- Its unique composition addresses key challenges in ECF management, including infection and impaired healing.
- Further clinical translation is warranted based on its demonstrated efficacy and safety in preclinical studies.
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