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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

282
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
282
Vaccinations01:51

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Overview
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Transcytosis of IgG01:15

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
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Related Experiment Video

Updated: May 28, 2025

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
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Research Priorities for Maternal Immunization.

Janet A Englund1,2, Alisa Kachikis3

  • 1From the Department of Pediatrics.

The Pediatric Infectious Disease Journal
|February 14, 2025
PubMed
Summary
This summary is machine-generated.

Maternal immunization research identifies knowledge gaps in vaccine use, administration, and antibody transfer. Further expert collaboration is crucial for advancing new maternal vaccines.

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Area of Science:

  • Obstetrics and Gynecology
  • Immunology
  • Vaccinology

Background:

  • The maternal immunization platform is established, with ongoing consideration for additional vaccines.
  • Existing maternal vaccines are in use, highlighting the importance of this public health strategy.

Purpose of the Study:

  • To identify and delineate critical knowledge gaps in maternal immunization.
  • To guide future research and policy development for enhanced maternal vaccine strategies.

Main Methods:

  • A comprehensive review of current maternal immunization research.
  • Identification of key areas requiring further investigation: pathogen targets, vaccine products, administration strategies, implementation science, and policy.

Main Results:

  • Significant questions persist regarding vaccine administration, product selection, coadministration, and vaccine acceptance in pregnant individuals.
  • Further research is needed to understand maternal antibody transfer, particularly in high-risk pregnancies.

Conclusions:

  • Advancing the development and implementation of new maternal vaccines requires a multidisciplinary approach.
  • Collaboration among diverse experts is essential for overcoming current challenges in maternal immunization.