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Updated: May 28, 2025

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Atroposelective Diverse Remote meta-C-H Functionalization via Kinetic Resolution

Jian-Jun Li1, Xiao-Xuan Zeng1, Xin Kuang1

  • 1State Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, CAS 345 Lingling Road, Shanghai 200032, P. R. China.

Journal of the American Chemical Society
|February 14, 2025
PubMed
Summary

This study introduces a novel method for creating chiral molecules with meta-functionalized biaryl scaffolds using palladium catalysis and kinetic resolution. This breakthrough enables the synthesis of complex atropisomers for pharmaceuticals and materials science.

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