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Hybrid-RViT: Hybridizing ResNet-50 and Vision Transformer for Enhanced Alzheimer's disease detection
Hongjie Yan1, Vivens Mubonanyikuzo2, Temitope Emmanuel Komolafe3
1Department of Neurology, Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, China.
Plos One
|February 14, 2025
Summary
A new deep learning model, Hybrid-RViT, accurately detects Alzheimer's disease (AD) stages using brain MRI scans. This advanced AI tool shows high accuracy, improving early diagnosis and treatment strategies for AD.
Area of Science:
- Medical Imaging
- Artificial Intelligence
- Neurology
Background:
- Alzheimer's disease (AD) is a major global health concern, necessitating early detection for effective management.
- Current diagnostic methods for AD can be improved with advanced analytical tools.
Purpose of the Study:
- To develop and evaluate a novel deep learning (DL) model, Hybrid-RViT, for enhanced detection and classification of Alzheimer's disease stages.
- To leverage a hybrid approach combining Convolutional Neural Networks and Vision Transformers for improved feature extraction from brain MRI data.
Main Methods:
- The Hybrid-RViT model was developed by integrating ResNet-50 for feature extraction and Vision Transformer (ViT) for capturing long-range dependencies in brain MRI images.
- Transfer learning using ResNet-50 was employed to enhance inductive bias and feature representation.
- The ViT component processed image patches using self-attention mechanisms for joint local-global feature extraction.
Main Results:
- The Hybrid-RViT model achieved a high training accuracy of 97% and a testing accuracy of 95%.
- The model demonstrated superior performance compared to existing methods in classifying Alzheimer's disease stages from MRI data.
- The Hybrid-RViT model effectively identified and classified different stages of AD.
Conclusions:
- The Hybrid-RViT model shows significant potential as a valuable tool for medical professionals in analyzing brain MRI images for Alzheimer's disease detection.
- This deep learning approach can substantially improve the accuracy and efficiency of early AD diagnosis and intervention.
- The hybrid architecture offers a promising direction for advancing AI-driven diagnostic tools in neurodegenerative disease research.

