Related Experiment Video
Updated: May 28, 2025
Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
Published on: October 22, 2020
Current clinical and pathogenetic characteristics of patients with chronic pancreatitis depending on biological age
Liliia Babinets1, Iryna Halabitska1, Nataliia Shevchenko2
1I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE.
Objective:
Aim: To investigate the relationships between age, smoking status, inflammatory markers, and endotoxicosis in patients with chronic pancreatitis, focusing on C-reactive protein (CRP) and middle molecular peptides, specifically MMP254 and MMP280..
Patients And Methods:
Materials and Methods: The study involved the examination of 108 patients diagnosed with chronic pancreatitis. These patients were categorized by age according to the World Health Organization (WHO) guidelines. Additionally, patients were stratified based on smoking status. Key biochemical markers were assessed, including fecal α-elastase, medium molecular weight peptides, and C-reactive protein levels. This approach allows for a comprehensive evaluation of how age and smoking may influence the course of chronic pancreatitis, while also considering the diagnostic value of these specific biomarkers in monitoring pancreatic function and inflammatory responses in these patients.
Results:
Results: A statistically significant impact of age on fecal α-elastase, C-reactive protein, and medium molecular peptides levels has been identified. Additionally, smoking has been shown to exacerbate pathological changes in these markers.
Conclusion:
Conclusions: these findings underscore the necessity for individualized treatment approaches that consider age and smoking history, particularly in older patients. Future research should further explore the underlying mechanisms linking these variables to chronic pancreatitis, with an emphasis on the long-term effects of smoking cessation and interventions targeting inflammatory markers and endotoxicosis. This understanding is crucial for enhancing management strategies and improving the quality of life for patients suffering from chronic pancreatitis.
More Related Videos
10:37Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
Published on: January 16, 2015
09:07Author Spotlight: Development and Characterization of an In Vitro Model to Study Chronic Cigarette Smoke Exposure and Its Impact on Airway Epithelial Cells in COPD Research
Published on: July 12, 2024
Related Concept Videos
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
01:20COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:22Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...