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Association between fibrinogen and cognitive impairment in patients with ischemic cerebrovascular disease

Keying Wu1, Jing Wang2, Xiuwen Li1

  • 1Sun Yat-sen University, School of Public Health, Guangzhou, Guangdong 510080, China.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|February 14, 2025
PubMed

Insights

Elevated fibrinogen levels are linked to cognitive impairment in ischemic cerebrovascular disease (ICVD) patients. Higher fibrinogen correlates with poorer global and executive function, and reduced white matter volume.

Area of Science:

  • Neurology
  • Neuroscience
  • Cardiovascular Research

Background:

  • Fibrinogen is a potential risk factor for vascular dementia (VaD).
  • The relationship between fibrinogen and cognitive function in ischemic cerebrovascular disease (ICVD) patients requires further investigation.

Purpose of the Study:

  • To examine the association between fibrinogen levels and cognitive impairment in ICVD patients.
  • To investigate the role of white matter hyperintensities (WMH) and brain atrophy in this association.

Main Methods:

  • A case-control study involving ICVD patients.
  • Cognitive function assessed using the Montreal Cognitive Assessment.
  • Brain magnetic resonance imaging (MRI) used to quantify WMH and brain atrophy.
  • Conditional logistic regression and generalized additive models employed to analyze associations.

Main Results:

  • Increased risk of cognitive impairment with higher fibrinogen levels (AOR = 1.92).
  • Fibrinogen levels > 4 g/L significantly increased cognitive impairment risk (AOR = 5.72).
  • Negative correlations observed between fibrinogen and global cognitive function (rs = -0.235), visuospatial/executive function (rs = -0.251), and normal-appearing white matter (NAWM) volume (rs = -0.282).

Conclusions:

  • Fibrinogen is significantly associated with cognitive impairment in ICVD patients.
  • Fibrinogen negatively impacts global cognitive function, visuospatial/executive function, and NAWM volume.
  • Further research into the mechanistic pathways linking fibrinogen and cognitive decline is warranted.
Abstract

Keywords:
Brain atrophyCognitive impairmentFibrinogenIschemic cerebrovascular diseaseWhite matter hyperintensities

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