Hydroxypropyl methylcellulose reinforced collagen/PVA composite hydrogel wound dressing with self-adaptive,...

Nowadays, hydrogels have been extensively and increasingly applied in the field of wound dressings in terms of their high biocompatibility and adjustable functionality. Bacterial infection can serious hinder wound healing the incomplete contact between hydrogel and wound increased the risk of infection. Thus, hydrogel wound dressings with antibacterial and can self-adapt to wound are urgently desired and still a challenge. Herein, a series of hydroxypropyl methylcellulose (HPMC) reinforced hydrogel wound dressings (CPH hydrogels) based on collagen/polyvinyl alcohol (COL/PVA) were designed and constructed, which with polyhexamethylene biguanide (PHMB) as antibacterial agent and borax as crosslinking agent. The dynamic cross-linking of reversible borate ester bond and hydrogen bonds endowed the CPH hydrogels with high adaptability and dynamic self-healing properties. The hydrogel exhibited good blood and cell biocompatibility, which with hemolysis rate lower than 5.0 % and cell survival rate higher than 90 %. The hydrogel also possessed excellent antibacterial ability for both E. coli and S. aureus by destroying the integrity of bacterial membrane. More importantly, the hydrogel with the formulation of 5 % COL, 5 %/PVA, 4 % borax and 1.75 % HPMC successfully achieved in promoting wound healing and accelerated collagen deposition, which provided a promising candidate to serve as wound dressing for wound healing.