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Alternative Splicing Dynamics in Plant Adaptive Responses to Stress
Abdulrahman Alhabsi1, Yu Ling2, Martin Crespi3,4
1Laboratory for Genome Engineering and Synthetic Biology, Division of Biological Sciences, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia;
Annual Review of Plant Biology
|February 14, 2025
Summary
Plants use alternative splicing (AS) to adapt to environmental stress. Understanding AS mechanisms and leveraging CRISPR-Cas tools can engineer crops for enhanced stress resilience and sustainable agriculture.
Area of Science:
- Plant molecular biology
- Gene regulation
- Genomics
Background:
- Plants possess complex molecular networks for stress adaptation.
- Gene regulation, including pre-mRNA splicing, is crucial for shaping plant responses.
- Alternative splicing (AS) diversifies the proteome, with 80% of plant genes exhibiting this phenomenon.
Purpose of the Study:
- To review the mechanisms of pre-mRNA splicing and AS in plants, focusing on stress responses.
- To explore the potential of AS in engineering stress-resilient crops for sustainable agriculture.
Main Methods:
- Review of existing literature on plant splicing mechanisms.
- Discussion of CRISPR-Cas technologies for dissecting AS regulation.
- Analysis of AS's role in plant development and stress adaptation.
Main Results:
- Alternative splicing is a key mechanism for plant adaptation to environmental stresses.
- CRISPR-Cas technologies provide powerful tools to investigate AS.
- AS plays a significant role in plant development and stress responses.
Conclusions:
- Insights into AS mechanisms can be leveraged to engineer crops with improved stress resilience.
- Harnessing AS offers a pathway toward sustainable agriculture in a changing climate.
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